| Home |
Syllabus |
Journal
Articles |
Solutions to Problem Sets |
| Date | Topic |
Reading | Problems | ||
| 1 |
Jan |
15 |
Intro, models, probability and distributions | Ch 1 | |
| 2 |
20 |
More on Distributions | |||
| 3 |
22 |
Genetic and phenotypic variation | Ch 2 | p. 45, 1-12 | |
| 4 |
27 |
Hardy Weinberg, basic and complex models | |||
| 5 |
29 |
Selection - basic diploid model | Ch 3 | p. 86, 1-15 | |
| 6 |
Feb |
3 |
Selection - dominance | ||
| 7 |
5 |
Selection - heterosis and underdominance | p. 126, 1-7 | ||
| 8 |
10 |
Selection - X linked genes, haplodiploids, multiple alleles | |||
| 9 |
12 |
Selection - viability, sexual, and gametic selection | Ch 4 | p. 126, 8-15 | |
| 10 |
17 |
Selection - estimation from natural populations | |||
| 11 |
19 |
Selection - ecological genetics and natural examples | p. 176, 1-7 | ||
| 12 |
24 |
Non-random mating | Ch 5 | ||
| 13 |
26 |
Non-random mating | p. 176, 8-15 | ||
| 14 |
Mar |
2 |
Genetic Drift: binomial sampling | Ch 6 | |
| 15 |
4 |
Genetic Drift and effective population size | p. 223, 1-15 | ||
| 16 |
9 |
Open | |||
| 17 |
11 |
Mid Term Exam |
p. 262, 1-12 | ||
| 16 | Spring Break | ||||
| 18 | Spring Break | ||||
| 18 |
23 |
Population Structure - models of migration | Ch 7 | ||
| 19 |
25 |
Population Structure - estimation of gene flow |
p. 305, 1-7 |
||
| 20 |
30 |
Mutation - basic ideas, mutation-selection balance | Ch 8 | ||
| 21 |
Apr |
1 |
Mutation - balance between mutation and drift | p. 305, 8-15 | |
| 22 |
6 |
Mutation - estimation of rates | |||
| 23 |
8 |
Molecular population genetics - neutral theory, mol. clock | Ch 9 | p. 338, 1-15 | |
| 24 |
13 |
Molecular population genetics - the coalescent process | |||
| 25 |
15 |
Molecular population genetics - tests of selection | Ch 9 | p. 392, 1-7 | |
| 26 |
20 |
Molecular population genetics - tests of selection (Wood) | |||
| 27 |
22 |
Multiple gene models - linkage disequilibrium | Ch 10 | p. 392, 8-15 | |
| 28 |
27 |
Epistasis and selection | |||
| 29 |
29 |
Human molecular variation (Wood) | p. 443, 8-15 | ||
| 30 |
May |
4 |
Open | ||
|
FINAL EXAM:
Tuesday, May 11, |
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| 1. |
Attendance. |
Regular attendance in lecture is expected and necessary for learning the material. Some of the topics covered in lecture are not in the text or other readings. |
| 2. |
Text. |
There are weekly readings from the text. You are encouraged to read slowly, take notes, and work through the math yourself to make sure you understand it. It is a good idea to read the relevant sections of the text before the corresponding lecture on that topic. |
| 3. |
Primary Literature. |
There are also weekly readings from the primary literature. These papers are listed below, are on electronic reserve in the main library (Course: ECOL 426, Password: popgen), and will be posted on the class website. Some exam questions will derive solely from this material. |
| 4. |
Written Summaries of Research Papers. |
Students are expected to turn in a one-page summary of each of the papers from the primary literature. These summaries are intended to help you distill the main points from each paper. The summary should be divided into four sections, addressing each of the following: (i) What major question is being addressed by the authors? (ii) What did the authors do? (iii) What did the authors find? (iv) What is the significance of the work? These sections will often correspond to the Introduction, Materials and Methods, Results and Discussion sections of research papers, although you will see that some of the readings do not follow this format. The readings will include both classic papers in population genetics as well as more recent papers. |
| 5. |
Presentations (required only for graduate students). |
All graduate students will briefly present one of the assigned papers to the class. These presentations will be on Thursdays during the last fifteen minutes of class. |
| 6. |
Exams. |
Both
the mid-term and the final exams will be in-class exams.
Graduate students will be required to answer
an additional question on each exam. The
final exam will cover material from the entire course,
with an
emphasis on material covered in the second half. |
| 7. |
Problems Sets. |
There
will be weekly problems sets
to be completed as take-home
exercises. Doing the problems is an
essential part of this course. Population
genetics involves a fair amount of simple
mathematics, and
like math, cannot be learned without working through examples. Each problem set will be worth ten points and
will be due at the start of class each Thursday. Points
will be deducted for late
assignments. You are free (and
encouraged) to work with other students when doing the problems. The problems will be graded each week and
returned to you. After they are
returned, the solutions will be posted on the course website. These solutions will be useful study guides
for the exams. |
| 8. |
Code of conduct. |
8. All
students are expected to adhere to the |
| Grading: | Mid term exam | 100 pts |
| Final Exam | 200 pts | |
| Problem Sets | 140 pts | |
| Written summaries | 30 pts | |
| Participation and attendance | 30 pts | |
| 500 pts |