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opportunities and contact information |
Trypanosoma
cruzi Research
We are
also interested in the evolution of human parasites, with a focus in Trypanosoma
cruzi, the agent of Chagas’
disease.
We are interested
in understanding the evolutionary history of T. cruzi.
This parasite mainly reproduces clonally, but evidence based on data from
nuclear mitochondrial genes have shown that hybridization events have
occurred during the recent evolutionary history of the parasite. We are
interested in trying to determine the history of hybridization of T.
cruzi and to understand how hybridization has affected its genome
structure. We have collected nucleotide sequences from a large number
of nuclear genes and we are trying to measure the rate at which gene exchange
has occurred during the evolution of the parasite and among which lineages
it has occurred. Futhermore, we are mining the recently sequenced genomes
of T. cruzi and two other kinetoplastid parasites (T. brucei,
Leishmania major) to identify fastly evolving genes.
Useful
Trypanosoma cruzi links
GeneDB
at the Sanger Institute
TIGR Trypanosoma cruzi
project
T. cruzi
research at the Oswaldo Cruz Institute
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