Tovah Salcedo

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CONTACT INFORMATION

    Ecology and Evolutionary Biology
    333 Biosciences West
    1041 E. Lowell
    University of Arizona
    Tucson, AZ 85721
    Tel: (520) 626-4747
    FAX: (520) 621-9190
    E-mail: tovahs@email.arizona.edu

RESEARCH INTERESTS

    I am interested in understanding how different evolutionary forces have shaped patterns of nucleotide variability within natural populations and across the genome.  Currently, I am exploring the role of antagonstic coevolution between wild house mice and their pathogens, from the perspective of the mouse host.  Genes involved in immune responses have elevated rates of protein evolution across many diverse taxa, which suggests that such genes are the targets of adaptive evolution.  However, it remains unclear what evolutionary forces affect immunity genes within populations.  My dissertation is describing on the evolution of genes involved in innate immunity in house mice and comparing these to non-immunity control genes.  I am using a candidate gene approach coupled with a phenotypic screen to explore the relationship between particular pathogens and mouse defenses.

PUBLICATIONS

    Snoeyenbos-West, O.L.O.,* Salcedo, T.,* McManus, G.B., and Katz, L.A. (2002) Insights into the diversity of choreotrich and oligotrich ciliates (Class: Spirotrichea) based on genealogical analyses of multiple loci. Int J Syst Evol Microbiol. 52: 1901-1913 (* denotes shared first authorship)

    Cutter, A.D., Payseur, B.A., Salcedo, T., Estes, A.M., Good, J.M., Wood, E., Hartl, T., Maughan, H., Strempel, J., Wang, B., Bryan, A.C., and M. Dellos. (2003) Molecular correlates of genes exhibiting RNAi phenotypes in Caenorhabditis elegans. Genome Res 13: 2651-2657.

    Salcedo, T., Geraldes, A., and M.W. Nachman. (2007) Nucleotide variation in wild and inbred mice. Genetics 177: 2277-2291.

PRESENTATIONS

    Salcedo, T., Snoeyenbos-West, O., McManus, G. and Katz, L.. Phylogenetic relationships among members of the ciliate class Spirotrichea based on multiple molecular markers. 9th East Coast Conference on Protozoology, Bryant College RI, June 2001. (talk)

    Salcedo, T., Snoeyenbos-West, O., McManus, G.B. and Katz, L.A.. Phylogenetic relationships among members of the ciliate class Spirotrichea based on multiple molecular markers. SSE/SSB/ASN, Knoxville, TN, June 2001. (talk)

    Salcedo, T., Katz, L.A.. Molecular evolution in ciliates at multiple markers. International Society for Evolutionary Protistology XIV, Vancouver, Canada, June 2002. (talk)

    Salcedo, T., Lasek-Nesselquist, E., Riley, J.L., and Katz, L.A. Widespread distribution of extensive chromosomal fragmentation in ciliates. Dartmouth College Life Sciences Symposium, Hanover, NH, September 1999. (poster)

    Salcedo, T., McManus, G.B. and Katz, L.A. What's inside that lorica? Evolutionary relationships among choreotrichs based on molecular data. International Society of Evolutionary Protistology, Ceske Budejovice, Czech Republic, August 2000. (poster)

    Salcedo, T., Snoeyenbos-West, O.L.O., McManus, G.B. and Katz, L.A. Evolutionary relationships among members of the ciliate class Spirotrichea based on multiple molecular markers. Council for Undergraduates Posters on the Hill session, Washington, DC, March 2001. (poster)

    Snoeyenbos-West, O., Salcedo, T., McManus, G. and Katz, L. Biogeography and level of endemism in ciliate populations from coastal environments. 9th East Coast Conference on Protozoology, Bryant College, RI, June 2001. (poster)

    Salcedo, T., Snoeyenbos-West, O., Katz, L. The tale of two tubulins. 12th Annual New England Molecular Evolutionary Biologists Meeting, Smith College, MA, November 2001. (poster)

    Salcedo, T. and Nachman, M.W. Nucleotide variation at the Duchenne muscular dystrophy locus (Dmd) in a natural population of house mice, Mus domesticus. SSE/SSB/ASN, Chico, CA, June 2003. Also presented at: SMBE, Newport Beach, CA, June 2003. (poster)

    Salcedo, T. and Nachman, M.W. Nucleotide variation at the Duchenne muscular dystrophy locus (Dmd) in a natural population of house mice, Mus domesticus. (updated) Evolutionary Genomics, Tucson, AZ, January 2004. (poster)

    Salcedo, T. and Nachman, M.W. Nucleotide variation on the X chromsome in laboratory strains and natural populations of house mice, Mus domesticus and Mus musculus. SMBE, State College, PA, June 2004. (poster)

    Salcedo, T. and Nachman, M.W. Nucleotide variability on the X chromosome in natural populations of house mice. SSE/SSB/ASN, Fairbanks, AK, June 2005. (talk)

    Salcedo, T. and Nachman, M.W. Balancing selection at Ceacam1, a gene conferring resistance to hepatitis virus in house mice.  SMBE, Halifax, NS, Canada, June 2007. (poster)

HONORS/AWARDS

    National Merit semifinalist, 1998

    Council for Undergraduate Research Posters on the Hill finalist, 2001, Washington, DC

    Best Student Talk, 9th East Coast Protozoology Conference, RI

    Blakeslee Foundation grant, summers 1999 and 2002 (competitive)

    Howard Hughes Medical Institute grant, summers 2000 and 2001, (competitive)

    Smith College Dean's List, 2001 and 2002

    Honors program, Smith College Dept Biological Sciences, fall 2001 - spring 2002

    Tomlinson grant recipient for honors thesis work (competitive)

    Honorable Mention, NSF Graduate Research Fellowship Program, 2002

    Margaret W. Brigham Award (Excellence in Microbiology), Smith College, 2002

    Awarded IGERT-Genomics two-year fellowship (NSF; administered through the University of Arizona), fall 2002

    Honorable Mention, NSF Graduate Research Fellowship Program, 2003

    University of Arizona/Alfred P. Sloan Foundation American Indian Graduate Partnership, fall 2005 - present

    Outstanding Graduate Academic Award, University of Arizona Native American Student Affairs, 2006

    NSF Doctoral Dissertation Improvement Grant, 2007

TEACHING EXPERIENCE

    2003 ECOL485/585 Mammalogy (University of Arizona)

    2005 ECOL335 Evolution (University of Arizona)

    2005 ECOL485/585 Mammalogy (University of Arizona)

EDUCATION

    2002 Smith College (Northampton, MA) BA (major: biology) Graduated with high honors from the Department of Biological Sciences

    Thesis title: Insights into the molecular evolution and phylogeny of ciliate classes Heterotrichea and Karyorelictea.

    University of Arizona, Department of Ecology & Evolutionary Biology (Tucson, AZ) PhD (expected May 2008)