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Tuesday "Noon" Seminar: March 27, 2007Latifa Borgelin on "Identifying Candidates for Malaria Driven Selection on Human Genes"
12:30-1:45 p.m. in Biosciences West (map of building location), Room 208 Talk AbstractInfectious disease driven selection has been critical in shaping human genetics. Malaria, as a widely endemic infectious disease, is a prominent player in infection driven selection on human disease phenotypes. Here we report on two potential candidates for malarial selection in a Nigerian (West African) population using SNP typing data from the International HapMap Consortium. Transforming Growth Factor beta 1 and E Selectin have been identified to have strong signals of positive directional selection using a long range haplotype test based appraoch to identify candidates for selection. |
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